| Draft Selection | Draft Source | Position | Player | Age | SI | Pot | Assignment | Team | Statistics | |
|---|---|---|---|---|---|---|---|---|---|---|
| 2070, Rd #3 | International | 3B | Bjørn Bergquist | 23 | 73 | 11 | AAA | East St. Louis Cardinals | ||
| 2070, Rd #2 | College | 3B | Ken Carl | 21 | 71 → 72 | 14 | AA | East St. Louis Cardinals | ||
| 2070, Rd #1 | College | P | Connor Humphreys | 20 | 64 → 67 | 14 | Majors | East St. Louis Cardinals | G 7, W 0, L 1, ERA 11.91, IP 11⅓, K 3 | |
| 2069, Rd #5 | College | 3B | Omar Arevalo | 21 | 62 | 11 | - | - | ||
| 2069, Rd #4 | College | OF | Ian Underwood | 21 | 79 → 85 | 12 | Majors | East St. Louis Cardinals | G 4, AVE .154, H 2, R 1, RBI 1 | |
| 2069, Rd #3 | College | P | Bryce Giles | 21 | 49 → 53 | 11 | Rookie | East St. Louis Cardinals | ||
| 2069, Rd #2 | Latin American Academy | P | Pascual Arevalo | 22 | 49 → 56 | 13 → 12 | A | East St. Louis Cardinals | ||
| 2069, Rd #1 | Asian Posting System | P | Hiromichi Tachibana | 27 | 74 → 92 | 13 | Majors | East St. Louis Cardinals | G 45, W 8, L 4, S 1, ERA 3.81, IP 106⅓, K 47 | |
| 2068, Rd #8 | Latin American Academy | 1B | Manuel Arellano | 19 | 57 → 60 | 11 | Rookie | East St. Louis Cardinals | ||
| 2068, Rd #7 | Latin American Academy | 3B | Marco Duran | 21 | 67 → 75 | 11 | AA | East St. Louis Cardinals | ||
| 2068, Rd #6 | High School | OF | Lane Echols | 19 | 47 | 10 → 9 | - | - | ||
| 2068, Rd #5 | Latin American Academy | P | Marcelo Acevedo | 21 | 41 | 10 | - | - | ||
| 2068, Rd #4 | Latin American Academy | SS | Pedro Flores | 21 | 66 → 82 | 12 | AAA | East St. Louis Cardinals | ||
| 2068, Rd #3 | Asian Posting System | P | Hendri Jayadi | 28 | 76 | 12 | - | - | ||
| 2068, Rd #2 | College | OF | Stacy Finney | 22 | 59 → 69 | 12 | - | - | ||
| 2068, Rd #1 | College | P | Harold Friedrich | 22 | 55 → 63 | 13 → 12 | A | East St. Louis Cardinals | ||
| 2067, Rd #7 | High School | OF | Mauricio Madrigal | 20 | 69 → 77 | 10 → 11 | AA | East St. Louis Cardinals | ||
| 2067, Rd #6 | College | OF | Logan Kiser | 23 | 81 → 94 | 12 | Majors | East St. Louis Cardinals | G 37, AVE .261, H 30, HR 2, R 12, RBI 12 | |
| 2067, Rd #5 | High School | P | Rich Mears | 20 | 39 → 50 | 10 → 11 | A | East St. Louis Cardinals | ||
| 2067, Rd #4 | High School | 1B | Reginald Jones | 20 | 51 → 67 | 11 | AA | East St. Louis Cardinals | ||
| 2067, Rd #3 | High School | OF | Cade Gregori | 20 | 64 → 73 | 14 → 13 | AA | East St. Louis Cardinals | ||
| 2067, Rd #2 | Junior College | P | Ralph Parrish | 21 | 40 → 64 | 13 | AA | East St. Louis Cardinals | ||
| 2067, Rd #1 | High School | P | Antonio Meza | 20 | 49 → 76 | 15 | Majors | East St. Louis Cardinals | G 12, W 3, L 2, ERA 3.86, IP 16⅓, K 10 | |
| 2066, Rd #8 | Latin American Academy | OF | Mateo Ordoñez | 21 | 61 | 9 | - | - | ||
| 2066, Rd #5 | Latin American Academy | OF | Caesar Hurtado | 25 | 72 → 78 | 11 | - | - | ||